The Science behind IMM-101

IMM-101 Mode of Action

  • IMM-101 is a systemic, broad-spectrum immunomodulator containing heat-killed, whole cell Mycobacterium obuense, that has shown promise as an effective and safe approach to enhance the antitumour response, including in pancreatic cancer.
  • IMM-101’s diverse immune related mechanism of action and the safe promotion of a broad systemic innate and adaptive type 1 immune response provides a strong rationale for targeting difficult to treat cancers including those that may be considered immunologically ‘cold’, such as pancreatic cancer.
  • IMM-101 targets cells of the innate immune system, such as dendritic cells, γδ T-cells, NK cells driving a broad immune response leading to cytotoxic effects on tumours.
  • IMM-101’s mode of action allows it to prime the body’s immune response, giving it the potential to enhance the efficacy of established anti-cancer regimens, including conventional cytotoxics as well as targeted immune-therapies such as checkpoint inhibitors, across a broad range of cancer indications.
  • IMM-101 induces a robust local and systemic type 1 immune response in pre-clinical models. Pre-clinical data suggest that IMM-101 engages TLR2 and increases the ability of dendritic cells to activate CD8+ cytotoxic T cells (involved in cancer cell recognition and co-ordination of the antitumor response). Existing data indicate that toll-like receptors (TLRs), key modulators of innate immunity, are strongly involved in the pathophysiology and development of PDAC.
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